Uecer, Ekrem and Fredersdorf, Sabine and Jungbauer, Carsten Gerald and Seegers, Joachim and Debl, Kurt and Riegger, Guenter and Maier, Lars Siegfried (2015) Unmasking the dormant pulmonary vein conduction with adenosine administration after pulmonary vein isolation with laser energy. EUROPACE, 17 (9). pp. 1376-1382. ISSN 1099-5129, 1532-2092
Full text not available from this repository. (Request a copy)Abstract
The isolation of the pulmonary veins (PVs) is the mainstay of atrial fibrillation (AF) ablation, which with current ablation techniques can be achieved in almost all cases. Reconnection of PVs constitutes the most frequent cause of AF recurrence. Visually guided laser balloon ablation (VGLA) is a novel system with very high rate of persistence of pulmonary vein isolation (PVI) three months after the first procedure shown in preclinical and clinical studies. We aimed to determine the acute efficiency of the laser energy during PVI with the help of adenosine provocation. Twenty-six patients (19 male; mean age 64 +/- 9 years) with symptomatic paroxysmal AF were included in the study. Pulmonary vein isolation was performed using the VGLA system. After successful PVI, we studied the effects of intravenous adenosine (18 mg) on activation of each PV at least 20 min after PVI. A total of 104 PVs were targeted. The balloon catheter could not be placed in two PVs. Of the remaining 102 PVs 99 (97% of the ablated PVs) could be successfully isolated. Adenosine was administered for each isolated PV in 25 patients. Only six PVs (6.7%) in five patients (20%) showed a PV reconnection during adenosine provocation. Pulmonary vein isolation with VGLA is a feasible technique for PVI with a very effective acute lesion formation. The clinical significance of this low reconnection rate has to be determined.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ATRIAL-FIBRILLATION; CATHETER ABLATION; BALLOON CATHETER; FOLLOW-UP; RECURRENCE; EXPERIENCE; POINT; Atrial fibrillation; Ablation; Laser; Endoscopic visualization; Adenosine; Reconnection |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 11 Jun 2019 12:54 |
| Last Modified: | 11 Jun 2019 12:54 |
| URI: | https://pred.uni-regensburg.de/id/eprint/4879 |
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