Burger, Ralf and Vince, Giles Hamilton and Meixensberger, Juergen and Bendszus, Martin and Roosen, Klaus (1999) Interrelations of laser doppler flowmetry and brain tissue oxygen pressure during ischemia and reperfusion induced by an experimental mass lesion. JOURNAL OF NEUROTRAUMA, 16 (12). pp. 1149-1164. ISSN 0897-7151, 1557-9042
Full text not available from this repository. (Request a copy)Abstract
The objective of this study was to assess interrelations between bilateral changes of cortical laser doppler flowmetry and intraparenchymal, subcortical partial tissue oxygen tension in the course of an experimental trauma. Ten animals served as a sham group, 8 Sprague-Dawley rats received an unilateral, focal parietal mass lesion. The bilateral course of cortical blood flow measured by laser doppler flowmetry (LDF) was correlated with subcortical, intraparenchymal partial tissue oxygen tension [p(ti)O-2]. In the sham-operated group, laser doppler mean flow values drifted between 9.0% and 9.5% and showed no significant changes over time neither between the hemispheres nor within each hemisphere. Absolute mean p(ti)O-2 in sham-operated animals was 32.4 mm Hg in the left and 30.5 mm Hg in the right hemisphere. In the trauma group, mean laser doppler flow values during maximum brain compression decreased ipsilateral to 20.3% and contralateral to 34.4% of the baseline values. P(ti)O-2 decreased ipsilateral from 25.9 to 6.6 mmHg (25.4%) and contralateral from 22.6 to 9.8 mm Hg (43.6%). After balloon deflation, cortical LDF was restored much faster compared to p(ti)Oz, but did not reach baseline values [ipsilateral 61.6% (p < 0.05); contralateral 75.8% of baseline values]. The p(ti)O-2 values reached 25.2 mm Hg (97%) ipsilateral and 23.7 mm Hg (105%) contralateral. A temporary phase of reactive hyperemia occurred sporadically shortly after decompression. Both parameters showed a significant but rather weak correlation (r = 0.56; p < 0.001). Based upon these findings, we conclude that intraparenchymal, subcortical p(ti)O-2 measurements supplemented on-line cortical CBF monitoring and score out discontinuous alternative measurement techniques in detecting hemodynamically relevant events. The small spatial resolution of LDF and p(ti)Oz probes, however, which in the small animal model may be of negligible influence, does raise the question whether the values obtained represent the microcirculatory situation of the human brain.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CEREBRAL BLOOD-FLOW; INCREASED INTRACRANIAL-PRESSURE; EXPERIMENTAL INTRACEREBRAL HEMORRHAGE; SEVERE HEAD-INJURY; COMATOSE PATIENTS; NEUROSURGICAL PATIENTS; SUBSTRATE DELIVERY; CUSHING RESPONSE; EXPANDING MASS; MICROCIRCULATION; balloon expansion; ischemia-reperfusion; laser-doppler flowmetry; mass lesion; microcirculation; oxygen metabolism |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 06 Dec 2022 12:48 |
| Last Modified: | 06 Dec 2022 12:48 |
| URI: | https://pred.uni-regensburg.de/id/eprint/48797 |
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