Russ, H. and Mueller, T. and Woitalla, D. and Rahbar, A. and Hahn, J. and Kuhn, W. (1999) Detection of tolcapone in the cerebrospinal fluid of parkinsonian subjects. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 360 (6). pp. 719-720. ISSN 0028-1298,
Full text not available from this repository.Abstract
The cerebral availability of the peripherally and centrally acting catechol-O-methyltransferase (COMT) inhibitor tolcapone is not known in humans. Therefore, we determined the concentration of tolcapone in cerebrospinal fluid (CSF) of 12 parkinsonian subjects 1-4 h after oral application of 200 mg of the drug. The mean concentration was 56.4+/-35.5 nmol/l (mean +/- SD), This concentration was calculated to cause 75.2+/-15% (mean +/- SD) inhibition of COMT in CSF. Thus, tolcapone efficiently inhibits COMT after crossing the blood-brain barrier in humans.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | DISEASE; tolcapone; cerebrospinal fluid; Parkinson's disease |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 06 Dec 2022 13:13 |
| Last Modified: | 06 Dec 2022 13:13 |
| URI: | https://pred.uni-regensburg.de/id/eprint/48805 |
Actions (login required)
 |
View Item |
