Rohrmeier, Thomas and Putzhammer, A. and Schoeler, A. and Sartor, H. and Dallinger, P. and Noethen, M. M. and Propping, P. and Knapp, M. and Albus, M. and Borrmann, M. and Knothe, K. and Kreiner, R. and Franzek, E. and Lichtermann, O. and Rietschel, M. and Maier, W. and Klein, H. E. and Eichhammer, P. (1999) hSKCa3: No association of the polymorphic CAG repeat with bipolar affective disorder and schizophrenia. PSYCHIATRIC GENETICS, 9 (4). pp. 169-175. ISSN 0955-8829,
Full text not available from this repository. (Request a copy)Abstract
hSKCa3 is a neuronal small conductance calcium-activated potassium channel, which contains a polyglutamine tract, encoded by a polymorphic CAG repeat in the gene. Since an association between longer alleles of this CAG repeat and bipolar disorder or schizophrenia has been reported, we genotyped the polymorphic CAG repeat in 91 German family trios of patients with bipolar disorder I and used the transmission disequilibrium test (TDT) to test for association. Applying a dichotomized model (less than or equal to 19 or >19 CAG triplets), we found no evidence for an association of longer alleles with bipolar disorder (TDT = 0.75, P = 0.386). Regarding the whole range of alleles, there was no preference in transmitting the larger of the two observed alleles from parents to the affected offspring. In parallel we performed an independent case-control study on German patients with bipolar disorder and schizophrenia. Again,ve did not detect an overrepresentation of longer CAG repeats in patients. Thus, our data do not support the hypothesis that longer CAG repeats in the hSkCa3 gene contribute to the susceptibility for bipolar disorder and schizophrenia. (C) 1999 Lippincott Williams & Wilkins.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CHANNEL GENE HSKCA3; TRANSMISSION DISEQUILIBRIUM; LINKAGE DISEQUILIBRIUM; SMALL-CONDUCTANCE; HKCA3 GENE; ANTICIPATION; hSKCa3; bipolar disorder; schizophrenia; transmission disequilibrium test; association; trinucleotide repeat |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 06 Dec 2022 13:49 |
| Last Modified: | 06 Dec 2022 13:49 |
| URI: | https://pred.uni-regensburg.de/id/eprint/48818 |
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