von Bahr, L. and Blennow, O. and Alm, J. and Bjorklund, A. and Malmberg, K-J and Mougiakakos, D. and Le Blanc, A. and Oefner, P. J. and Labopin, M. and Ljungman, P. and Le Blanc, K. (2015) Increased incidence of chronic GvHD and CMV disease in patients with vitamin D deficiency before allogeneic stem cell transplantation. BONE MARROW TRANSPLANTATION, 50 (9). pp. 1217-1223. ISSN 0268-3369, 1476-5365
Full text not available from this repository. (Request a copy)Abstract
Vitamin D has emerged as a central player in the immune system, with its deficiency being implicated in the pathogenesis of several autoimmune diseases, including chronic GvHD. This is a retrospective cohort analysis of 166 patients, who underwent allogeneic hematopoietic stem cell transplantation (HSCT) at the Karolinska University Hospital, evaluating GvHD, graft failure, infectious complications and survival after HSCT in relation to pre-transplantation vitamin D levels. Most of the patients were deficient in vitamin D before HSCT (median 42 nmol/L). In multivariate analysis, vitamin D level before HSCT was identified as a significant independent risk factor for development of cGvHD. The increased incidence of cGvHD was not coupled to better disease-free survival; instead there was a trend towards lower overall survival in the vitamin D-deficient patients. In addition, we found a significant correlation between vitamin D deficiency and incidence of CMV disease, with no case of CMV disease occurring in patients with sufficient levels of vitamin D before HSCT. Our results support a role of vitamin D in immune tolerance following HSCT. These findings could be highly relevant for the care of HSCT patients, and prospective, randomized studies on the effect of vitamin D supplementation are therefore needed.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | VERSUS-HOST-DISEASE; REGULATORY T-CELLS; DENDRITIC CELLS; MULTIPLE-SCLEROSIS; IMMUNE-SYSTEM; MYELOID CELLS; RISK; PEPTIDE; DEFINITIONS; ACTIVATION; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Funktionelle Genomik (Prof. Oefner) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 11 Jun 2019 13:00 |
| Last Modified: | 11 Jun 2019 13:00 |
| URI: | https://pred.uni-regensburg.de/id/eprint/4884 |
Actions (login required)
 |
View Item |
