Schunkert, Heribert and Hense, Hans-Werner and Andus, Tilo and Riegger, Guenter A. J. and Straub, Rainer H. (1999) Relation between dehydroepiandrosterone sulfate and blood pressure levels in a population-based sample. AMERICAN JOURNAL OF HYPERTENSION, 12 (11). pp. 1140-1143. ISSN 0895-7061,
Full text not available from this repository. (Request a copy)Abstract
Endogenous dehydroepiandrosterone sulfate (DHEAS) levels have been reported to be positively related to blood pressure levels, To further analyze this association, we quantified DHEAS in middle-aged subjects (mean age +/- SEM: 57.8 +/- 0.1 years) of a population-based sample (n = 646). DHEAS levels were higher in hypertensive as compared with normotensive individuals (1.26 +/- 0.04 v 1.09 +/- 0.03 mu g/mL, P = .01). After adjustment for age, gender, and body mass index, DHEAS levels were significantly related to systolic blood pressure (P = .01). In addition, in a subgroup of individuals without antihypertensive medication adjusted DHEAS levels were significantly related to systolic and diastolic blood pressure (n = 461; P < .05, both), DHEAS levels were also related to aldosterone (r = 0.15; P = .002) and androstenedione (its main metabolite; r = 0.66; P < .001) but not to renin levels, Like DHEAS, aldosterone, but not androstenedione, was significantly related to blood pressure levels and hypertension status. In a regression analysis that accounted for aldosterone and renin levels, both DHEAS and aldosterone kept their significant relationships with systolic blood pressure levels. Taken together, we observed a consistent positive association between endogenous DHEAS and systolic blood pressure levels that was independent of other, similarly regulated, adrenal steroids. (C) 1999 American Journal of Hypertension, Ltd.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | POSTMENOPAUSAL WOMEN; RANCHO-BERNARDO; RISK-FACTORS; MEN; dehydroepiandrosterone sulfate; aldosterone; androstenedione; renin; hypertension |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 13 Dec 2022 07:04 |
| Last Modified: | 13 Dec 2022 07:04 |
| URI: | https://pred.uni-regensburg.de/id/eprint/48859 |
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