Grimm, Daniela and Holmer, Stephan R. and Riegger, Guenter A. J. and Kromer, Eckhard P. (1999) Effects of beta-receptor blockade and angiotensin II type I receptor antagonism in isoproterenol - Induced heart failure in the rat. CARDIOVASCULAR PATHOLOGY, 8 (6). pp. 315-323. ISSN 1054-8807,
Full text not available from this repository. (Request a copy)Abstract
The aim of this study was to examine the effects of both angiotensin II type I receptor antagonism using losartan (LOS) and beta-receptor blockade by metoprolol (MP) in isoproterenol-induced cardiac injury in the rat. Two weeks after isoproterenol (ISO) application, 90 ISO and 30 control (CTRL) rats were examined. ISO rats were treated for two weeks with either LOS, MP, or vehicle (n = 30 each group). Compared to CTRL, ISO induced left ventricular hypertrophy (LVH), fibrosis, and overexpression of extracellular matrix proteins. LOS significantly attenuated these changes. MP only reduced LVH, but exerted no effect on structural alterations. LV end-diastolic and mean right atrial pressures were significantly increased in the ISO group and normalized in the LOS and MP group. Mean aortic blood flow velocity was significantly decreased in the ISO group and unaltered in the LOS and MP group versus CTRL. Blood pressure was decreased in ISO and LOS rats. MP treatment had no effect on blood pressure, but significantly lowered heart rate. Isoproterenol induced mild heart failure. Losartan and metoprolol applications in ISO-treated rats were highly effective in attenuating hemodynamic alterations and LVH. Early application of losartan 24 hours after isoproterenol-induced cardiac injury revealed significant beneficial effects on myocardial structure. (C) 1999 Elsevier Science Inc.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CONVERTING ENZYME-INHIBITION; ACUTE MYOCARDIAL-INFARCTION; INDUCED CARDIAC-HYPERTROPHY; FUNCTIONAL-SIGNIFICANCE; LEFT-VENTRICLE; CAPTOPRIL; FIBROSIS; CARDIOMYOPATHY; LOSARTAN; SURVIVAL; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 13 Dec 2022 07:55 |
| Last Modified: | 13 Dec 2022 07:55 |
| URI: | https://pred.uni-regensburg.de/id/eprint/48869 |
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