Kriegmair, M. and Zaak, D. and Stepp, H. and Stepp, H. and Baumgartner, R. and Knuechel, Ruth and Hofstetter, A. (1999) Transurethral resection and surveillance of bladder cancer supported by 5-aminolevulinic acid-induced fluorescence endoscopy. EUROPEAN UROLOGY, 36 (5). pp. 386-392. ISSN 0302-2838,
Full text not available from this repository. (Request a copy)Abstract
Purpose: We determined whether neoplastic disease, which was missed under white light can be found during transurethral resection of bladder cancer by 5-aminolevulinic acid-induced porphyrin fluorescence. Materials and Methods: 5-Aminolevulinic acid-induced fluorescence endoscopy was carried out in 328 cases. A 3% 5-aminolevulinic acid solution was instilled intravesically in a mean time of 2.8 h before endoscopy, The fluorescence was excited by a special incoherent light source which provided blue light in addition to white light. Results: In 82 (25%) cases additional neoplastic lesions were found only because of their red porphyrin fluorescence which was induced by 5-aminolevulinic acid. 31% of these neoplastic foci which were found in normal and nonspecific inflamed mucosa had a poorly differentiated histology. Conclusions: 5-Aminolevulinjc acid facilitates detection of neoplastic disease during transurethral resection of bladder cancer and increases the accuracy of diagnosis.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TRANSITIONAL-CELL-CARCINOMA; INTRAVESICAL INSTILLATION; PROTOPORPHYRIN-IX; TUMORS; RECURRENCE; DIAGNOSIS; BIOPSIES; LESIONS; MUCOSA; 5-aminolevulinic acid; fluorescence; bladder neoplasm |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 13 Dec 2022 08:07 |
| Last Modified: | 13 Dec 2022 08:07 |
| URI: | https://pred.uni-regensburg.de/id/eprint/48875 |
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