Distler, O. and Rinkes, B. and Hohenleutner, Ulrich and Schoelmerich, Juergen and Landthaler, Michael and Lang, B. and Gay, S. and Mueller-Ladner, Ulf (1999) Expression of RANTES in biopsies of skin and upper gastrointestinal tract from patients with systemic sclerosis. RHEUMATOLOGY INTERNATIONAL, 19 (1-2). pp. 39-46. ISSN 0172-8172, 1437-160X
Full text not available from this repository. (Request a copy)Abstract
Inflammatory infiltrates and upregulated collagen production are hallmarks of systemic sclerosis (SSc). There are indications that chemokines are involved in accumulation of inflammatory and matrix-synthesizing cells in SSc skin lesions. Therefore, we searched for the expression and localization of the chemokine RANTES ("regulated upon activation and normal T cells expressed and secreted") in skin and esophageal biopsies from patients with SSc. Using immunohistochemistry and in situ hybridization, skin biopsies derived from clinically involved and noninvolved skin of Is patients with early and long-term SSc were examined for RANTES expression and compared with nondiseased skin sections of seven patients without SSc. In addition, esophageal snap biopsies were taken in a subgroup of six SSc patients. Strong expression of RANTES could be detected in the epidermis in keratinocytes of patients with short-term and long-term disease, both on the mRNA and protein level. The percentage of RANTES-expressing cells were significantly higher in clinically noninvolved skin sections than in involved skin areas. In contrast, no RANTES expression was found in esophageal biopsies or in the control group. The results indicate that RANTES is present in human sclerodermatous skin. RANTES may be involved in early pathogenesis of SSc as well as in fibrosis pathways, either by chemoattraction of immunocompetent cells and/or by modulation of collagen production.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MONOCYTE CHEMOATTRACTANT PROTEIN-1; IN-SITU EXPRESSION; RHEUMATOID-ARTHRITIS; DERMAL FIBROBLASTS; LANGERHANS CELLS; CHEMOKINE RANTES; GENE-EXPRESSION; GROWTH-FACTORS; IMMUNE-SYSTEM; MESSENGER-RNA; chemokines; systemic sclerosis; RANTES; keratinocytes |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Dermatologie und Venerologie Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 13 Dec 2022 11:00 |
| Last Modified: | 13 Dec 2022 11:00 |
| URI: | https://pred.uni-regensburg.de/id/eprint/48904 |
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