Mahboobi, Siavosh and Burgemeister, Thomas and Dove, Stefan and Kuhr, Sabine and Popp, Alfred (1999) Homoarcyriaflavin: Synthesis of ring-expanded arcyriaflavin analogues. JOURNAL OF ORGANIC CHEMISTRY, 64 (22). pp. 8130-8137. ISSN 0022-3263,
Full text not available from this repository. (Request a copy)Abstract
The construction of the ring-expanded carbazole system, forming arcyriaflavin homologues, is efficiently accomplished by the reaction of 2,2'-bridged bis-indoles with 3,4-dibromo-2,5-dihydro-1H-2,5-pyrroledione derivatives under Grignard conditions A ring size of up to nine members in the central ring is achievable. Substitutions either at the indole system or at the imide-N are also possible. The conformation of homoarcyriaflavins as a cross-link between the rigid arcyriaflavins and the flexible arcyriarubins was investigated by NMR, X-ray, and semiempiric quantum chemical calculation methods.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PROTEIN-KINASE-C; INHIBITORS; REBECCAMYCIN; POTENT; INDOLOCARBAZOLE; STAUROSPORINE; |
| Subjects: | 600 Technology > 615 Pharmacy |
| Divisions: | Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry I (Prof. Elz) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 13 Dec 2022 13:03 |
| Last Modified: | 13 Dec 2022 13:03 |
| URI: | https://pred.uni-regensburg.de/id/eprint/48911 |
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