Malfertheiner, M. and Malfertheiner, P. and Costa, S. D. and Pfeifer, M. and Ernst, W. and Seelbach-Goebel, B. and Malfertheiner, S. Fill (2015) Extraesophageal symptoms of gastroesophageal reflux disease during pregnancy. ZEITSCHRIFT FUR GASTROENTEROLOGIE, 53 (9). pp. 1080-1083. ISSN 0044-2771, 1439-7803
Full text not available from this repository. (Request a copy)Abstract
Aim: Typical symptoms of gastroesophageal reflux disease (GERD) are known to be frequent in pregnancy. The aim of this study was to gain a first estimation of the occurrence of extraesophageal symptoms in this context. Methods: A prospective longitudinal study was performed on 166 pregnant women and in a control group of 285 women. The diagnosis of GERD was based on the Montreal classification using the reflux disease questionnaire (RDQ). Extraesophageal symptoms were recorded with a self-administered questionnaire. Typical GERD symptoms and extraesophageal GERD symptoms were recorded in each trimester of pregnancy. Results: The prevalence of GERD during pregnancy was 16.9% in the first, 25.3% in the second and 51.2% in the third trimester. The prevalence of GERD in the control group was 6.3%. Asthma was reported by 3.5% of controls and by 6% of pregnant women during pregnancy. Chest pain occurred in 6% of the controls and in 1.8%, 2.4% and 2.4% during the trimesters of pregnancy, chronic cough was reported by 1.1% of controls and 1.2% of pregnant women. With the diagnosis of GERD the odds ratios and 95% confidence intervals for asthma, chronic cough and chest pain in the third trimester of pregnancy were as follows: 1.56 (0.58-4.22) for asthma, 0.91 (0.08-10.28) for chronic cough and 2.04 (0.49-8.46) for chest pain. Conclusion: GERD is very frequent during pregnancy with progressive incidence during the course of pregnancy. Extraesophageal symptoms of GERD have an unexpected low prevalence during pregnancy.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PROTON-PUMP INHIBITORS; ATYPICAL SYMPTOMS; CHRONIC COUGH; POPULATION; GERD; MANIFESTATIONS; DIAGNOSIS; gastroesophageal reflux; GERD; esophagus; pregnancy; asthma; chronic cough |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Frauenheilkunde und Geburtshilfe (Schwerpunkt Geburtshilfe) Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 11 Jun 2019 13:07 |
| Last Modified: | 11 Jun 2019 13:07 |
| URI: | https://pred.uni-regensburg.de/id/eprint/4892 |
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