Liebold, A. and Langhammer, T. and Brunger, F. and Birnbaum, Dietrich E. (1999) Cardiac interleukin-6 release and myocardial recovery after aortic crossclamping. Crystalloid versus blood cardioplegia. JOURNAL OF CARDIOVASCULAR SURGERY, 40 (5). pp. 633-636. ISSN 0021-9509,
Full text not available from this repository.Abstract
Background. Pro-inflammatory cytokines may play an important role in patient response to cardiopulmonary bypass (CPB), Since the myocardium is proposed to be a major source of cytokines, we studied the influence of the cardiolpegia type on interleukin-6 release and early myocardial recovery. Methods. Experimental design: prospective, randomized study. Setting: university hospital, operative and intensive care. Patients: 20 consecutive patients (3 females) scheduled for elective coronary artery bypass grafting (CABG), mean age 62.8+/-5 years, history of myocardial infarction 11/20, left ventricular ejection fraction 62.9+/-15%. Interventions: patients were operated on using randomly either cold blood cardioplegia (B, n=10) or cold crystalloid cardioplegia (C, n=10), Measures: plasma levels of interleukin-6 (IL-6) were measured prior to CPB, after aortic declamping, after CPB, 1 hour, 6 hours and 12 hours postoperatively. Results. Groups were comparable with respect to demographic data, left ventricular function, number of grafts, CPB and aortic crossclamp time. Group B patients demonstrated significant lower IL-6 levels after 1 hour (210+/-108 vs 578+/-443 pg/ml), 6 hours (204+/-91 vs 1210+/-671 pg/ml) and 12 hours (174+/-97 vs 971+/-623 pg/ml). Post-CPB cardiac index was superior in group B (3.9+/-0.3 vs 3.2+/-0.3 l/min/m(2), p<0.05) with similar doses of inotropes. Group B patients could earlier be weaned off respirator (10+/-4 vs 13+/-4 hours, p<0.05) and showed minor blood loss (635+/-211 vs 918+/-347 mi, p<0.05). Conclusions. Inflammatory response to CPB is associated with delayed myocardial recovery. The use of blood cardioplegia may attenuate inflammatory reactions.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CARDIOPULMONARY BYPASS; RESPONSES; CYTOKINES; cardiopulmonary bypass; interleukin-6; inflammation physiopathology |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Herz-, Thorax- und herznahe Gefäßchirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 20 Dec 2022 10:47 |
| Last Modified: | 20 Dec 2022 10:47 |
| URI: | https://pred.uni-regensburg.de/id/eprint/48956 |
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