Dragon, Stefanie and Carey, Cynthia and Martin, Kathy and Baumann, Rosemarie (1999) Effect of high altitude and in vivo adenosine/beta-adrenergic receptor blockade on ATP and 2,3BPG concentrations in red blood cells of avian embryos. JOURNAL OF EXPERIMENTAL BIOLOGY, 202 (20). pp. 2787-2795. ISSN 0022-0949,
Full text not available from this repository. (Request a copy)Abstract
In chick embryos, developmental changes of the blood oxygen tension control hemoglobin (Hb) oxygen affinity via modulation of ATP and 2,3BPG concentrations in red blood cells. Hypoxia, which is a normal developmental condition for late chick embryos, causes a decrease of the red cell ATP concentration (and increase of red cell oxygen affinity) as well as activation of 2,3BPG synthesis via cyclic AMP-dependent signaling. Adenosine and catecholamines have been implicated as signaling substances in these red cell responses, To assess the extent to which adenosine and catecholamines are involved in vivo in the control of red cell ATP/2,3BPG concentrations, day 13 chick embryos were treated for 24 h with adenosine A(2) and/or beta-adrenergic receptor blockers and red cell ATP and 2,3BPG levels were determined. The data suggest that adaptive effects later in development in chick embryos induced by adenosine and catecholamines are vital, We have also tested whether avian embryos of the free-living, high-altitude, native white-tailed ptarmigan (Lagopus leucurus) alter their organic phosphate pattern in red cells in response to incubation at different altitudes. Embryos incubated at 3600-4100 m decrease their red cell ATP concentration much more rapidly than embryos of the same clutch incubated at 1600 m, From these data it can be inferred that the oxygen affinity of high altitude embryos will be adjusted to the altitude at which the eggs are incubated.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | OXYGEN-TRANSPORT; CHICK-EMBRYO; EGG; ERYTHROCYTES; AFFINITY; EXCHANGE; HYPOXIA; GASES; oxygen tension; hypoxia; ATP; 2,3bisphosphoglycerate; chick embryo; white-tailed ptarmigan; Lagopus leucurus |
| Subjects: | 500 Science > 570 Life sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Physiologie > Alumni or Retired > Prof. Dr. Rosemarie Baumann |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 20 Dec 2022 11:07 |
| Last Modified: | 20 Dec 2022 11:07 |
| URI: | https://pred.uni-regensburg.de/id/eprint/48959 |
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