Berge, J. P. and Bourgougnon, N. and Alban, S. and Pojer, F. and Billaudel, S. and Chermann, J. C. and Robert, J. M. and Franz, Gerhard (1999) Antiviral and anticoagulant activities of a water-soluble fraction of the marine diatom Haslea ostrearia. PLANTA MEDICA, 65 (7). pp. 604-609. ISSN 0032-0943,
Full text not available from this repository.Abstract
A water-soluble fraction from the marine diatom Haslea ostrearia was capable to inhibit the in vitro replication of HSV-1 in Veto cells with 50 % inhibitory concentration (EC50) of 14 mu g/ml at a multiplicity of infection of 0.01 ID50/cells. In addition, this fraction delayed the HIV-l-induced syncitia formation on MT4 cells. At:concentrations up to 200 mu g/ml, no cytotoxicity was observed for both the Vero and MT4 cells. The fraction only inhibited the blood coagulation process at concentrations considerably exceeding the EC50.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | BLUE-GREEN-ALGAE; COLORIMETRIC ASSAY; CYANOPHYTA; SENSITIVITY; MICROALGAE; CULTURE; DRUGS; diatom; Haslea ostrearia; Naviculaceae; pennate; anti-HSV-1 activity; anti-HIV-1 activity; anticoagulant activity |
| Subjects: | 600 Technology > 615 Pharmacy |
| Divisions: | Chemistry and Pharmacy > Institute of Pharmacy > Alumni or Retired Professors > Prof. Franz |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 20 Dec 2022 16:26 |
| Last Modified: | 20 Dec 2022 16:26 |
| URI: | https://pred.uni-regensburg.de/id/eprint/48978 |
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