Berg, D. and Becker, G. and Zeiler, B. and Tucha, Oliver and Hofmann, E. and Preier, M. and Benz, P. and Jost, W. and Reiners, K. and Lange, Klaus W. (1999) Vulnerability of the nigrostriatal system as detected by transcranial ultrasound. NEUROLOGY, 53 (5). pp. 1026-1031. ISSN 0028-3878, 1526-632X
Full text not available from this repository.Abstract
Objective: To assess the incidence of a hyperechogenic substantia nigra (SN) by transcranial sonography (TCS) in healthy people and to evaluate whether an enlarged hyperechogenic SN area is associated with functional impairment of the nigrostriatal system. Background and Methods: Until now, preclinical impairment of the nigrostriatal system could be identified only by functional neuroimaging techniques such as PET in selected groups of patients. TCS is a new, noninvasive ultrasound technique that has demonstrated an increased echogenicity of the SN in patients with PD, whereas in most healthy individuals, the SN is either barely detectable or undetectable by TCS. Results: Of 330 healthy volunteers, 8.6% exhibited an increased echogenicity of the SN. From these, 10 clinically healthy individuals with distinct unilateral or bilateral hyperechogenic signals in the SN region (SN area above 0.25 cm(2)) underwent comprehensive motor testing, neuropsychological assessment, MRI, and [F-18]-dopa PET examination. With regard to motor functions, these individuals did not differ from 10 age- and sex-matched controls with a low echogenic SN and an area of echogenic signals below 0.2 cm(2). Enlargement of hyperechogenic areas in the 10 healthy individuals was associated with a marked decrease in the accumulation of [F-18]-dopa in the caudate nucleus and putamen. Conclusions: Substantia nigra hyperechogenicity appears to indicate a functional impairment of the nigrostriatal system. Transcranial sonography may be a suitable method of identifying persons at risk of nigrostriatal alterations, making possible the introduction of early neuroprotective therapy.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | POSITRON EMISSION TOMOGRAPHY; F-18 DOPA-PET; PARKINSONS-DISEASE; MAGNETIC-RESONANCE; SUBSTANTIA-NIGRA; IRON CONTENT; BRAIN; TIME; T2; HUNTINGTON; nigrostriatal system; preclinical impairment; transcranial ultrasound; MRI; [F-18]-dopa PET; neuropsychological assessment |
| Subjects: | 100 Philosophy & psychology > 150 Psychology |
| Divisions: | Human Sciences > Institut für Psychologie > Lehrstuhl für Psychologie III (Biologische, Klinische und Rehabilitationspsychologie) - Prof. Dr. Klaus W. Lange |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 21 Dec 2022 06:15 |
| Last Modified: | 21 Dec 2022 06:15 |
| URI: | https://pred.uni-regensburg.de/id/eprint/48994 |
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