Goepferich, Achim and Peter, Susan J. and Lucke, Andrea and Lu, Lichun and Mikos, Antonios G. (1999) Modulation of marrow stromal cell function using poly(D,L-lactic acid)-block-poly(ethylene glycol)-monomethyl ether surfaces. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, 46 (3). pp. 390-398. ISSN 0021-9304,
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The adhesion of marrow stromal osteoblasts and the adsorption of fetal bovine serum (FBS) proteins to end-capped poly(D,L-lactic acid) 50:50 (PLA50) of molecular weight 17,009 (PLA50(17)), non-encapped PLA50 of molecular weight 11,000 (PLA50(11h)), and a diblock copolymer made of poly(ethylene glycol)-monomethyl ether of molecular weight 5,000 and PLA50 of molecular weight 20,000 (Me.PEG5-PLA20) were investigated. Cell attachment and proliferation on both PLA50 polymers were equally good. The block copolymer did not allow the proliferation of cells. However, the attached cells were highly differentiated and metabolically active in,contrast to the cells on PLA50. Moreover, surface analysis:studies using electron spectroscopy revealed;that FBS proteins adsorbed well from aqueous solutions to the PLA50 surfaces while they adsorbed substantially less to the block copolymer. These results suggest that Me.PEG-PLA block copolymers may be used to regulate protein adsorption and, therefore, cell adhesion by varying the block composition of the copolymer, (C) 1999 John Wiley & Sons, Inc. J Biomed Mater Res, 46, 390-398,1999.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PLA/PEO/PLA TRIBLOCK COPOLYMERS; HYDROLYTIC DEGRADATION; POLY(ETHYLENE GLYCOL); BLOCK-COPOLYMERS; DRUG-DELIVERY; stromal cell; block copolymer; protein adsorption; cell adhesion; degradable polymer |
| Subjects: | 600 Technology > 615 Pharmacy |
| Divisions: | Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Technology (Prof. Göpferich) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 21 Dec 2022 06:48 |
| Last Modified: | 21 Dec 2022 06:48 |
| URI: | https://pred.uni-regensburg.de/id/eprint/49001 |
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