Schaedlich, Hiltrud and Ermann, Joerg and Biskop, Maria and Falk, Werner and Sperling, Frauke and Juengel, Astrid and Lehmann, Joerg and Emmrich, Frank and Sack, Ulrich (1999) Anti-inflammatory effects of systemic anti-tumour necrosis factor alpha treatment in human murine SCID arthritis. ANNALS OF THE RHEUMATIC DISEASES, 58 (7). pp. 428-434. ISSN 0003-4967,
Full text not available from this repository.Abstract
Objectives-To evaluate in vivo the contribution of tumour necrosis factor alpha (TNF alpha) to the chimeric transfer model of human rheumatoid arthritis synovial membrane into SCID mice (hu/mu SCID arthritis), systemic anti-TNF alpha treatment was performed and the clinical, serological, and histopathological effects of this treatment assessed. Methods-Animals were treated with the rat-antimouse TNF alpha monoclonal antibody V1q, starting on day 1 after hu/mu engraftment, twice weekly for 12 weeks. Joint swelling, serum concentrations of human and murine interleukin 6 (IL6), and serum amyloid P (SAP) were measured. Histopathological and immunohistochemical analyses of the joints were also performed at the end of treatment. Results Neutralisation of murine TNF alpha induced the following effects: (a) reduction of extent and duration of the acute arthritis phase, with significant reduction of joint swelling at two weeks; (b) decrease of murine SAP concentrations after the first antibody administration; and (c) increase of murine IL6 in the serum. At the end of treatment, there was a significant reduction of the inflammatory infiltration in the engrafted joints. Because of the mild degree of joint erosion, no treatment effects could be demonstrated on the destructive process. Conclusion-In the lymphocyte independent hu/mu SCID arthritis, anti-TNF alpha. treatment reduces local and systemic signs of inflammation.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | COLLAGEN-INDUCED ARTHRITIS; AMELIORATES JOINT DISEASE; AMYLOID-P-COMPONENT; GROWTH-FACTOR-BETA; RHEUMATOID-ARTHRITIS; TNF-ALPHA; CARTILAGE DESTRUCTION; SYNOVIAL TISSUE; ADJUVANT ARTHRITIS; MICE; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 31 Jan 2023 10:58 |
| Last Modified: | 31 Jan 2023 10:58 |
| URI: | https://pred.uni-regensburg.de/id/eprint/49138 |
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