Mahboobi, Siavosh and Eluwa, Stella and Kumar, Sunil and Koller, Markus and Stoerl, Karin (1999) beta-carbolinedione derivatives as topoisomerase I inhibitors. ARCHIV DER PHARMAZIE, 332 (7). pp. 249-254. ISSN 0365-6233,
Full text not available from this repository. (Request a copy)Abstract
Pyrrolo[3,4-c]-beta-carbolinedione dimers 5-14 were synthesized from furo[3,4-c]-beta-carbolinediones and diamines by solvent-free TaCl5/silica catalyzed reaction under microwave irradiation. The inhibitory property of these target compounds, the starting materials 2, 31, 32, and the N-alkylated pyrrolo[3,4-c]-beta-carbolinediones 16, 17, 20-30 was tested against the relaxation of supercoiled pRB322 DNA by calf thymus topoisomerases I and II. Some of these compounds, especially 7 and 23 proved to be selective inhibitors of topoisomerase I.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | DNA CLEAVAGE; POISONS; topoisomerase I inhibition; beta-carbolinedione derivatives; microwave irradiation |
| Subjects: | 600 Technology > 615 Pharmacy |
| Divisions: | Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry I (Prof. Elz) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 31 Jan 2023 11:01 |
| Last Modified: | 31 Jan 2023 11:01 |
| URI: | https://pred.uni-regensburg.de/id/eprint/49140 |
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