Bernhardt, Guenther and Koch, Marion and Spruss, Thilo and Gust, Ronald and Krauser, Rudolf and Schlemmer, Richard and Hollstein, Michael and Lux, Franz and Schoenenberger, Helmut (1999) [meso-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]sulfatoplatinum(II) - Pharmacokinetic studies. ARCHIV DER PHARMAZIE, 332 (6). pp. 195-200. ISSN 0365-6233,
Full text not available from this repository.Abstract
The maximally attainable level of the non-plasma protein bound fraction of a single 10.0 mu mol/kg i.p. dose of [meso-1,2-bis(2,6-di-chloro-4-hydroxyphenyl)ethylenediamine]sulfatoplatinum(II), a drug active or the murine, hormone-sensitive MXT-M-3.2 breast cancer, lies markedly below the concentration causing a significant cytotoxic effect on a cell line derived from this tumor. This result confirms our opinion that the strong in vivo activity of this drug on hormone-sensitive breast cancers is mediated by its estrogenic potency by analogy with high dosed steroidal and non-steroidal estrogens. A specific cytotoxic effect utilizing the estrogen receptor as carrier, as formerly postulated, is unlikely.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ANTICANCER DRUG CISPLATIN; PLATINUM(II) COMPLEXES; MAJOR ADDUCT; DNA; CANCER; CIS-DIAMMINEDICHLOROPLATINUM(II); KINETICS; ALBUMIN; CIS-<PT(NH3)2(H2O)2>(NO3)2; CYTOTOXICITY; [meso-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]sulfatoplatinum(II); pharmacokinetics; reactivity; anti-breast cancer activity; mode of action |
| Subjects: | 600 Technology > 615 Pharmacy |
| Divisions: | Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 07 Feb 2023 14:27 |
| Last Modified: | 07 Feb 2023 14:27 |
| URI: | https://pred.uni-regensburg.de/id/eprint/49181 |
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