Langstein, Joachim and Schwarz, Herbert (1999) Identification of CD137 as a potent monocyte survival factor. JOURNAL OF LEUKOCYTE BIOLOGY, 65 (6). pp. 829-833. ISSN 0741-5400,
Full text not available from this repository. (Request a copy)Abstract
CD137 (ILA/4-1BB), a member of the tumor necrosis factor (TNF) receptor family, promotes adherence and prolongs survival of human peripheral monocytes, It induces a strong expression of macrophage colony-stimulating factor (M-CSF), an essential monocyte survival factor. Monocyte survival induced by CD137 is primarily mediated by M-CSF and to a lesser extent by granulocyte-macrophage colony-stimulating factor and IL-3. Survival and induction of M-CSF are mediated via reverse signaling through a CD137 ligand expressed constitutively by peripheral monocytes.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | COLONY-STIMULATING FACTOR; FACTOR-RECEPTOR FAMILY; LYMPHOCYTE-PROLIFERATION; SOLUBLE FORM; HUMAN 4-1BB; MEMBER; ACTIVATION; GROWTH; ILA; DIFFERENTIATION; macrophage colony-stimulating factor; cytokine receptor; human |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Feb 2023 09:56 |
| Last Modified: | 14 Feb 2023 09:56 |
| URI: | https://pred.uni-regensburg.de/id/eprint/49206 |
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