Kumar, Sunil and Mueller, Klaus (1999) Lichen metabolites. 1. Inhibitory action against leukotriene B-4 biosynthesis by a non-redox mechanism. JOURNAL OF NATURAL PRODUCTS, 62 (6). pp. 817-820. ISSN 0163-3864, 1520-6025
Full text not available from this repository. (Request a copy)Abstract
Of several lichen metabolites isolated from Parmelia nepalensis and Parmelia tinctorum, the didepsides atranorin (4) and diffractaic acid (5), as well as (+)-protolichesterinic acid (7), inhibited LTB4 biosynthesis in polymorphonuclear leukocytes. Ethyl hematommate (3) and (+)-usnic acid (1) were only weak inhibitors, while methyl beta-orcinolcarboxylate (2) and gyrophoric acid (6) were inactive at concentrations up to 60 mu M. Redox properties of the compounds were evaluated in terms of inhibition of nonenzymatic lipid peroxidation in model membranes, reactivity against the stable free radical 2,2-diphenyl-1-picrylhydrazyl, and deoxyribose degradation as a measure of hydroxyl-radical generation. The results revealed that lichen metabolites neither acted as antioxidants against the peroxidation process in model membranes nor did they scavenge or produce free radicals, suggesting that the inhibitory effects on LTB4 biosynthesis was due to specific enzyme interaction rather than a nonspecific redox mechanism.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ANTIPSORIATIC ANTHRONES; EPIDERMAL 12-LIPOXYGENASE; OXYGEN RADICALS; 5-LIPOXYGENASE; ACID; INACTIVATION; CONSTITUENTS; ANTHRALIN; CYCLOOXYGENASE; MEMBRANES; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Chemistry and Pharmacy > Institute of Pharmacy |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Feb 2023 10:28 |
| Last Modified: | 14 Feb 2023 10:28 |
| URI: | https://pred.uni-regensburg.de/id/eprint/49211 |
Actions (login required)
 |
View Item |
