Kumar, Sunil and Mueller, Klaus (1999) Lichen metabolites. 2. Antiproliferative and cytotoxic activity of gyrophoric, usnic, and diffractaic acid on human keratinocyte growth. JOURNAL OF NATURAL PRODUCTS, 62 (6). pp. 821-823. ISSN 0163-3864, 1520-6025
Full text not available from this repository. (Request a copy)Abstract
The sensitivity of the human keratinocyte cell line HaCaT to several lichen metabolites isolated from Parmelia nepalensis and Parmelia tinctorum was evaluated. The tridepside gyrophoric acid (6), the dibenzofuran derivative (+)-usnic acid (1), and the didepside diffractaic acid (5) were potent antiproliferative agents and inhibited cell growth, with IC50 values of 1.7, 2.1, and 2.6 mu M, respectively. Methyl beta-orcinolcarboxylate (2), ethyl hematommate (3), the didepside atranorin (4), and (+)-protolichesterinic acid (7) did not influence keratinocyte growth at concentrations of 5 mu M. Keratinocytes were further tested for their susceptibility to the action of the potent antiproliferative agents on plasma membrane integrity. The release of lactate dehydrogenase activity into the culture medium was unchanged as compared to controls, documenting that the activity of gyrophoric acid (6), (+)-usnic acid (1), and diffractaic acid (5) was due to cytostatic rather than cytotoxic effects.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MODULATED REDOX PROPERTIES; ANTIPSORIATIC ANTHRONES; 5-LIPOXYGENASE; INHIBITORS; APOPTOSIS; PSORIASIS; 1,8-DIHYDROXY-9(10H)-ANTHRACENONES; PROLIFERATION; CONSTITUENTS; DERIVATIVES; |
| Subjects: | 600 Technology > 615 Pharmacy |
| Divisions: | Chemistry and Pharmacy > Institute of Pharmacy |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Feb 2023 10:50 |
| Last Modified: | 14 Feb 2023 10:50 |
| URI: | https://pred.uni-regensburg.de/id/eprint/49212 |
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