Kuhn, Wilfried and Woitalla, D. and Russ, H. and Gerlach, M. and Mueller, Th. (1998) Potential risks of central active COMT inhibitors. AKTUELLE NEUROLOGIE, 25. S277-S278. ISSN 0302-4350,
Full text not available from this repository.Abstract
Both theoretical considerations and experimental data suggest potential neurotoxicity of intracerebral acting inhibitors of Catechol-O-Methyltransferase (COMT). Those drugs might induce increasing oxidative stress or higher levels of S-Adenosylmethionin, a COMT-cofactor with putative neurotoxicity. Subsequently, an increased formation of protoxins and toxins may result. Moreover, it has been shown that COMT-inhibitor tolcapone does impair mitochondrial energy production in vitro.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CATECHOL-O-METHYLTRANSFERASE; L-DOPA; METHYLATION; DEPLETION; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Feb 2023 15:34 |
| Last Modified: | 14 Feb 2023 15:34 |
| URI: | https://pred.uni-regensburg.de/id/eprint/49268 |
Actions (login required)
 |
View Item |
