Fleck, Martin and Kern, Earl R. and Zhou, Tong and Lang, Bernhard and Mountz, John D. (1998) Murine cytomegalovirus induces a Sjogren's syndrome-like disease in C57B1/6-lpr/lpr mice. ARTHRITIS AND RHEUMATISM, 41 (12). pp. 2175-2184. ISSN 0004-3591, 1529-0131
Full text not available from this repository.Abstract
Objective. To analyze Fas and tumor necrosis factor receptor I (TNFRI) apoptosis pathways in salivary gland inflammatory disease induced by murine cytomegalovirus (MCMV) infection. Methods. Four different strains of mice (C57Bl/6 [B6]-+/+, Fas-deficient B6-lpr/lpr, TNFRI-deficient B6-tnfr1(0/0), and B6-tnfr1(0/0)-lpr/lpr mice) were infected intraperitoneally with the Smith strain of MCMV (1 x 10(5) plaque-forming units). Viral load was determined by a plaque assay, inflammation and apoptosis by immunohistochemistry and staining with terminal dUTP nick-end labeling, and autoantibodies by enzyme-linked immunosorbent assay. Results. Infectious MCMV was not detectable by day 100, Although all MCMV-infected mice developed acute sialadenitis by day 28, a chronic (>100 days), severe salivary gland inflammation and anti-Re and anti-La antibodies developed only in the B6-lpr/lpr mice. Apoptotic cells were detected during the acute, but not the chronic, phase of inflammation. Conclusion. Both Fas- and TNFRI-mediated apoptosis contribute to the clearance of MCMV-infected cells in the salivary glands. However, because Fas-mediated apoptosis is necessary for the downmodulation of the immune response, a defect in this process can lead to a postinfection, chronic inflammatory response that resembles Sjogren's syndrome.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | EPSTEIN-BARR-VIRUS; LABIAL SALIVARY-GLANDS; LIVER-DISEASE; LPR MICE; T-CELLS; APOPTOSIS; SIALADENITIS; EXPRESSION; INFECTION; BCL-2; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 21 Feb 2023 06:37 |
| Last Modified: | 21 Feb 2023 06:37 |
| URI: | https://pred.uni-regensburg.de/id/eprint/49274 |
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