Gramatzki, M. and Ludwig, W. D. and Burger, R. and Moos, P. and Rohwer, P. and Gruenert, C. and Sendler, A. and Kalden, J. R. and Andreesen, Reinhard and Henschke, F. and Moldenhauer, G. (1998) Antibodies TC-12 ("unique") and TH-111 (CD96) characterize T-cell acute lymphoblastic leukemia and a subgroup of acute myeloid leukemia. EXPERIMENTAL HEMATOLOGY, 26 (13). pp. 1209-1214. ISSN 0301-472X,
Full text not available from this repository.Abstract
To extend the panel of monoclonal antibodies useful for immunophenotyping of acute leukemias, two new reagents, TC-12 and TH-111, were developed. TC-12 was found "unique," and TH-111 was assigned to the recently defined CD96 cluster. Both reagents show little reactivity with blood and bone marrow nucleated cells but define a major (TH-111: 78.3%) or an important (TC-12: 45.6%) subset of T-cell acute lymphoblastic leukemia (ALL). In addition, in acute myeloid leukemia (AML), the expression of TC-12 was found in 64 (20.2%) of 317 and TH-111 in 97 (29.1%) of 333 of these patients. TC-12 positivity in AML was virtually restricted to the Fab subtypes MO, M1, M2, and M6. In the group of immature AML characterized by the coexpression of CD7 as well as CD117 and CD34 positivity, leukemic blasts frequently disclosed the TC-12 and TH-111 antigen. Although the TC-12 antigen could not be determined, TH-111 immunoprecipitated the TACTILE (CD96) antigen and, when expressed, was found to be associated with the transferrin receptor. These reagents may help not only to define and dissect T-cell ALL, but also to characterize a subgroup of immature AML at the divergence of T-cell and myeloid lineage.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CHILDREN; ANTIGEN; monoclonal antibodies; acute leukemias; T-cell acute lymphoblastic leukemia; immunophenotyping |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 21 Feb 2023 07:23 |
| Last Modified: | 21 Feb 2023 07:23 |
| URI: | https://pred.uni-regensburg.de/id/eprint/49290 |
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