Schlegel, J. and Muenkel, K. and Trenkle, T. and Fauser, G. and Ruschoff, J. (1998) Expression of the ERBB2/neu and neurofibromatosis type 1 gene products in reactive and neoplastic Schwann cell proliferation. INTERNATIONAL JOURNAL OF ONCOLOGY, 13 (6). pp. 1281-1284. ISSN 1019-6439,
Full text not available from this repository.Abstract
In the present study we investigated the expression of the ERBB2 protein and neurofibromin in human benign and malignant Schwann cell tumors, traumatic neuromas and peripheral nerves without pathological findings. By immunohistochemistry and Western analysis ERBB2 expression was not detectable in normal nerves but in proliferating Schwann cells of traumatic neuromas. While none of the malignant schwannomas exhibited ERBB2 expression, weak expression was seen in a small proportion of the benign schwannomas. Low levels of neurofibromin were detectable in normal nerves but not in traumatic neuromas or tumors. These data indicate an inverse expression pattern of ERBB2 and neurofibromin in human non-neoplastic Schwann cells, but not in neurinoma cells.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | GTPASE-ACTIVATING PROTEIN; NEUREGULIN RECEPTOR; CARDIAC DEVELOPMENT; MICE LACKING; ONCOPROTEIN; SYSTEM; FAMILY; Schwann cells; neurinoma; proliferation; neurofibromin; ERBB2 |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 21 Feb 2023 07:29 |
| Last Modified: | 21 Feb 2023 07:29 |
| URI: | https://pred.uni-regensburg.de/id/eprint/49297 |
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