von Hoersten, Stephan and Nave, Heike and Ballof, Jan and Helfritz, Fabian and Meyer, Dirk and Schmidt, Reinhold E. and Stalp, Michael and Exton, Natalie G. and Exton, Michael S. and Straub, Rainer H. and Radulovic, Jelena and Pabst, Reinhard (1998) Centrally applied NPY mimics immunoactivation induced by non-analgesic doses of met-enkephalin. NEUROREPORT, 9 (17). pp. 3881-3885. ISSN 0959-4965,
Full text not available from this repository.Abstract
NEUROPEPTIDE Y (NPY) and endogenous opioids (EOPs) such as methionine-enkephalin (Met-enk) regulate similar physiological responses, but it is not known whether nociceptive and immune responses also show analogy after intracerebroventricular (i.c.v.) application. Dose-response studies show that Met-enk stimulates the blood granulocyte and splenic natural killer (NK) cell function of Lewis rats at a low dose (10(2) ng/kg, i.c.v.), whereas a high dose (10(5) ng/kg) causes suppression of innate immune functions associated with analgesia in the hot-plate test. At 15 min, 1 h and 24 h after i.c.v. application, both Met-enk (102 ng/kg) and NPY (1 ng/kg) produced similar effects: An initial suppression of innate immune function Nas followed by a long lasting stimulatory action on cell functions and serum interleukin-6 (sIL-6) levels. Thus, central NPY application resembles Met-enk-induced immunostimulation at doses not affecting nociception, suggesting an involvement of both peptides in shaping stress-induced immunomodulation of the non-analgetic form, possibly via activation of a common immunomodulatory effector mechanism. NeuroReport 9: 3881-3885 (C) 1998 Lippincott Williams & Wilkins.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | NEUROPEPTIDE-Y; METHIONINE-ENKEPHALIN; OPIOID RECEPTORS; IMMUNE-RESPONSES; BRAIN; RATS; MICE; MODULATION; PEPTIDES; SYSTEM; endogenous opioids; granulocyte chemiluminescence; hot-plate test; interleukin-6; methionine-enkephalin; NK cell cytotoxicity; neuroimmunomodulation; neuropeptide Y; nociception; stress |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 21 Feb 2023 09:09 |
| Last Modified: | 21 Feb 2023 09:09 |
| URI: | https://pred.uni-regensburg.de/id/eprint/49316 |
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