Müller, Klaus and Breu, Klaus (1998) 10-omega-phenylalkyl-9(10H)-anthracenones as inhibitors of keratinocyte growth with reduced membrane damaging properties. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 8 (22). pp. 3211-3216. ISSN 0960-894X, 1464-3405
Full text not available from this repository.Abstract
Work aimed at further improving the benefit to risk ratio of the antipsoriatic agent anthralin has led to 10-omega-phenylalkyl-9(10H)-anthracenones, members of which are equally potent as inhibitors of the growth of HaCaT keratinocytes. In contrast to anthralin, induction of membrane injury is strongly reduced as documented by the release of LDH activity from cytoplasm of keratinocytes. (C) 1998 Elsevier Science Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MODULATED REDOX PROPERTIES; ANTIPSORIATIC ANTHRONES; ANTIPROLIFERATIVE ACTIVITY; ANTHRALIN; 5-LIPOXYGENASE; DITHRANOL; RADICALS; 1,8-DIHYDROXY-9(10H)-ANTHRACENONES; DERIVATIVES |
| Subjects: | 500 Science > 540 Chemistry & allied sciences 600 Technology > 615 Pharmacy |
| Divisions: | Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry I (Prof. Elz) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 16 Feb 2023 06:16 |
| Last Modified: | 16 Feb 2023 06:16 |
| URI: | https://pred.uni-regensburg.de/id/eprint/49341 |
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