Hobbhahn, Jonny and Wiesner, Gunther and Taeger, Kai (1998) Occupational exposure and environmental pollution: the role of inhalation anaesthetics with special consideration of sevoflurane. ANAESTHESIST, 47. S77-S86. ISSN 0003-2417,
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There are a number of assays available to study genetic toxicity of inhalation anaesthetics. Those discussed in this review are the Ames Salmonella mutagenesis test and assays for structural chromosome aberrations, micronuclei (MN) and sister chromatid exchanges (SCEs). None of these assays showed abnormalities induced by volatile inhalation anaesthetics. Only Compound A induced a slight increase in the number of SCEs. However, the implications of this in vitro study are unclear. Results of studies focussing on the effects of long-term occupational exposure to inhalation anaesthetics are controversial. Neither harmfulness nor safety of chronic exposure to low concentrations of inhalation anaesthetics have been proven. Although there is no clear evidence of harmfulness; there is general agreement that occupational exposure should be minimized for precautionary reasons;This particularly applies to N2O. Therefore occupational exposure standards have been established in many countries,though not yet for sevoflurane and desflurane. In Germany occupational exposure can be kept below the threshold values, when working in operation theatres with a standard air conditioning system, a high-flow scavenging system, low leakage anaesthesia machines and preventative maintenance of equipment. Under these conditions occupational exposure is low even when using laryngeal mask airways and uncuffed tracheal tribes. Sevoflurane is a halocarbon, but is only partially halogenated and the only halogen it contains is fluorine. Sevoflurane,therefore,appears to have an insignificant effect on ozone depletion and its contribution to the greenhouse effect is negligible.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SISTER-CHROMATID EXCHANGES; OPERATING-ROOM PERSONNEL; NITROUS-OXIDE EXPOSURE; WASTE-GAS EXPOSURE; CHROMOSOME-ABERRATIONS; SPONTANEOUS-ABORTION; DENTAL ASSISTANTS; SWEDISH MIDWIVES; ANESTHETIC-GASES; CANCER RISK; inhalation anaesthetics; genetic toxicity; long-term occupational exposure; environmental pollution |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Anästhesiologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 28 Mar 2023 14:16 |
| Last Modified: | 28 Mar 2023 14:16 |
| URI: | https://pred.uni-regensburg.de/id/eprint/49365 |
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