Kreft, Andreas and Mottok, Anja and Mesteri, Ildiko and Cardona, Diana M. and Janin, Anne and Kuehl, Anja A. and Andrulis, Mindaugas and Brunner, Andrea and Shulman, Howard M. and Negri, Giovanni and Tzankov, Alexandar and Huber, Elisabeth (2015) Consensus diagnostic histopathological criteria for acute gastrointestinal graft versus host disease improve interobserver reproducibility. VIRCHOWS ARCHIV, 467 (3). pp. 255-263. ISSN 0945-6317, 1432-2307
Full text not available from this repository. (Request a copy)Abstract
Graft versus host disease (GvHD) is a clinically important complication after allogeneic hematopoietic stem cell transplantation (HSCT). Its diagnosis relies on clinical and histopathological findings. In order to evaluate and improve inter-institutional diagnostic agreement on histological diagnosis and grading of acute gastrointestinal GvHD, we conducted a round robin test, which included 33 biopsies from 23 patients after HSCT. Five pathologists from different institutions independently evaluated the original sections from the biopsies submitted for diagnosis. Based on their results, consensus qualitative criteria for the assessment of typical histological features of GvHD (e.g., apoptosis, crypt destruction, mucosa denudation) were proposed, including detailed descriptions as well as histological images. In a second round robin test with involvement of the same pathologists, the reproducibility of both diagnosis and grading had improved. Remaining differences were mostly related to differential diagnostic considerations, including viral infection or toxic side effects of medication, which should be resolved by integrating histopathological findings with proper clinical information.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | BONE-MARROW-TRANSPLANTATION; WORKING GROUP-REPORT; DEVELOPMENT PROJECT; CLINICAL-TRIALS; APOPTOSIS; BIOPSIES; KAPPA; Intestinal GvHD; Diagnosis; Histology; Consensus criteria |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 13 Jun 2019 13:33 |
| Last Modified: | 13 Jun 2019 13:33 |
| URI: | https://pred.uni-regensburg.de/id/eprint/4937 |
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