Froehlich, Dieter and Rothe, G. and Schmitz, Gerd and Hansen, Ernil (1998) Volatile anaesthetics induce changes in the expression of P-selectin and glycoprotein Ib on the surface of platelets in vitro. EUROPEAN JOURNAL OF ANAESTHESIOLOGY, 15 (6). pp. 641-648. ISSN 0265-0215,
Full text not available from this repository. (Request a copy)Abstract
Halothane has been shown to inhibit platelet aggregation and may, therefore, prevent intraoperative platelet activation. The aim of this study was to compare the effects of volatile anaesthetics on platelet activation, including the transformation into an adhesive platelet phenotype. After in vitro exposure to volatile anaesthetics, the expression of the adhesion molecule P-selectin and the internalization of the receptor for the von Willebrand factor (GPlb) were analysed by flow cytometry In contrast to desflurane or N2O, sevoflurane (greater than or equal to 0.5 MAC, P < 0.05), halothane (greater than or equal to 1.0 MAC, P < 0.01) and isoflurane (greater than or equal to 2.0 MAC, P < 0.01) induced a significantly higher expression of P-selectin on the surface of platelets, indicating the degranulation of alpha-granules. In the presence of desflurane (greater than or equal to 0.5 MAC, P < 0.05), halothane (greater than or equal to 1.0 MAC, P < 0.01), isoflurane and sevoflurane (both greater than or equal to 2.0 MAC, P < 0.01), a redistribution of GPlb occurred, indicating platelet activation. N2O had no effect. In conclusion, several of the volatile anaesthetics tested in vitro induced changes in the expression of P-selectin and GPlb, being characteristic of platelet activation. None of the anaesthetics investigated interfered with the platelet response to ADP stimulation.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | GENERAL-ANESTHESIA; PARTITION-COEFFICIENTS; INHALED ANESTHETICS; REGIONAL ANESTHESIA; FIBRINOGEN BINDING; NITROUS-OXIDE; HUMAN-BLOOD; IX COMPLEX; OLIVE OIL; IN-VITRO; platelets; volatile anaesthetics; platelet aggregation; P-selectin; glycoprotein Ib |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Anästhesiologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 29 Mar 2023 04:55 |
| Last Modified: | 29 Mar 2023 04:55 |
| URI: | https://pred.uni-regensburg.de/id/eprint/49384 |
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