Greifenegger, Norbert and Jaeger, Michael and Kunz-Schughart, Leoni A. and Wolf, Hans and Schwarzmann, Fritz (1998) Epstein-Barr virus small RNA (EBER) genes: Differential regulation during lytic viral replication. JOURNAL OF VIROLOGY, 72 (11). pp. 9323-9328. ISSN 0022-538X, 1098-5514
Full text not available from this repository. (Request a copy)Abstract
In every latently Epstein-Barr virus-infected cell the viral genes EBER-1 and EBER-2 are transcribed by polymerase III, In lytically infected cells in vivo the EBER genes could not be detected. However, in cell culture downregulation could not be confirmed, and hence the relevance of this shutdown to the replication of the virus was not clear. We assayed the transcriptional activity of the EBER genes by nuclear run-on assays with enriched lytically infected cells and demonstrated that EBER-1 and EBER-2 are differentially downregulated on the transcriptional level during the switch to lytic viral replication. This downregulation was an early event during the lytic replication of the virus.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | BURKITT-LYMPHOMA CELLS; ENCODED SMALL RNAS; B-LYMPHOCYTES; CARRIER STATE; TRANSCRIPTION; EXPRESSION; HYBRIDIZATION; LOCALIZATION; INDUCTION; PROMOTER; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 18 Apr 2023 09:14 |
| Last Modified: | 18 Apr 2023 09:14 |
| URI: | https://pred.uni-regensburg.de/id/eprint/49397 |
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