Kumar, Sunil K. C. and Mueller, Klaus (1998) Inhibition of leukotriene biosynthesis and lipid peroxidation in biological models by the extract of Cassia fistula. PHYTOTHERAPY RESEARCH, 12 (7). pp. 526-528. ISSN 0951-418X,
Full text not available from this repository.Abstract
The methanol extract obtained from the fruits of Cassia fistula L. inhibited the 5-lipoxygenase catalysed formation of leukotriene B-4 in bovine polymorphonuclear leukocytes with an IC50 value of 38 mu g/mL. Also, lipid peroxidation in bovine brain phospholipid liposomes induced with 2,2'-azo-bis-(2-amidinopropane) dihydrochloride (AAPH) was inhibited with an IC50 value of 40 mu g/mL. A linear correlation was obtained between the effects of the extract in the two kinds of assays suggesting a redox-based mechanism for the inhibition of the 5-lipoxygenase enzyme. (C) 1998 John Wiley & Sons, Ltd.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ANTIOXIDANT ACTIVITY; FREE-RADICALS; 5-LIPOXYGENASE; DISEASE; TANNINS; Fabaceae; Cassia fistula; lipid peroxidation; 5-lipoxygenase; Nepalese plants |
| Subjects: | 600 Technology > 615 Pharmacy |
| Divisions: | Chemistry and Pharmacy > Institute of Pharmacy |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 18 Apr 2023 10:06 |
| Last Modified: | 18 Apr 2023 10:06 |
| URI: | https://pred.uni-regensburg.de/id/eprint/49403 |
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