Schaeffler, Andreas and Palitzsch, Klaus-Dieter and Seiffarth, C. and Hoehne, H. M. and Riedhammer, F. J. and Hofstaedter, Ferdinand and Schoelmerich, Juergen and Rueschoff, Josef (1998) Coexistent thyroiditis is associated with lower tumour stage in thyroid carcinoma. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 28 (10). pp. 838-844. ISSN 0014-2972, 1365-2362
Full text not available from this repository.Abstract
Background Microsatellite instability (MSI) is a new mechanism described in carcinogenesis of several rumours and seems to predispose for cancer in some chronic inflammatory diseases. As thyroiditis is thought to be both the cause and the consequence of thyroid carcinoma, it was the aim of this retrospective study to investigate the epidemiology and the influence of a coexistent thyroiditis on prognosis and clinicopathological parameters in an iodine-deficient area. Methods The grade of lymphocytic infiltration (LI) of 153 thyroid carcinomas was determined in paraffin-embedded tissues: G0=no LI, G1 = peritumoral LI, G2 = peritumoral LI with follicle, G3 = diffuse LI. A non-radioactive PCR-based screening method was used for detection of MSI. Results Twenty-seven (17.7%) out of 153 carcinomas were accompanied by thyroiditis (GI, 16; G2, 5; G3, 6). Ten cases fulfilled the criteria necessary for diagnosing Hashimoto's thyroiditis. Nine out of 10 (90%) Hashimoto's cases and 16 out of 17 (94%) other thyroiditis cases were associated with a significantly (chi(2) < 0.01) lower pT stage (pT1, pT2) than cases without thyroiditis. No statistical association was found by comparing multifocality or sclerosing variants with the grade of lymphocytic infiltration. MSI was detected neither in patients with severe inflammation nor in the absence of thyroiditis. Conclusions MSI does not seem to play a role in the pathogenesis of thyroid carcinoma. Coexistent thyroiditis is associated with a lower pT stage and thus could be an indicator of a better prognosis.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CHRONIC LYMPHOCYTIC THYROIDITIS; MICROSATELLITE INSTABILITY; HASHIMOTO THYROIDITIS; IODINE-PROPHYLAXIS; COLORECTAL-CARCINOMA; MISMATCH REPAIR; CANCER; P53; MUTATIONS; PROTEIN; Hashimoto's thyroiditis; lymphocytic thyroiditis; microsatellite instability; thyroid carcinoma; thyroiditis; prognosis |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 18 Apr 2023 10:51 |
| Last Modified: | 18 Apr 2023 10:51 |
| URI: | https://pred.uni-regensburg.de/id/eprint/49451 |
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