Rothoerl, Ralf Dirk and Woertgen, Chris and Holzschuh, Matthias and Metz, Christoph and Brawanski, Alexander (1998) S-100 serum levels after minor and major head injury. JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE, 45 (4). pp. 765-767. ISSN 1079-6061,
Full text not available from this repository.Abstract
Background: S-100, a protein of astroglial cells, is described as a marker for central nervous system damage, The aim of this study was to evaluate whether the marker could give information about the severity and possibility of functional recovery after minor and severe head injury. Methods: Thirty patients after severe head injury (Glasgow Coma Scale score < 9) and 11 patients after minor head injury (Glasgow Coma Stale score > 12) were included. In each case, blood samples were drawn within 6 hours after injury. Outcome was estimated at hospital discharge using the Glasgow Outcome Scale. Results: All patients who sustained minor head injury had reached a favorable outcome by the time they were discharged from the hospital. Their mean S-100 serum level was 0.35 mu g/L. Patients who sustained severe head injury and were classified as having an unfavorable outcome (31%) showed a mean serum concentration of 4.9 mu g/L, whereas patients classified as having a favorable outcome (69%) had a mean S-100 level of 1.2 mu g/L. All groups differed significantly (p < 0.05) Conclusion: S-100 appears to be a promising marker for the severity of head injury and neuronal damage.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | NEURON-SPECIFIC ENOLASE; ISCHEMIC BRAIN-DAMAGE; CREATINE-KINASE BB; CEREBROSPINAL-FLUID; PROTEIN; INCREASES; NSE; CSF; severe head injury; minor head injury; S-100 |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Anästhesiologie Medicine > Lehrstuhl für Neurochirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 18 Apr 2023 13:19 |
| Last Modified: | 18 Apr 2023 13:19 |
| URI: | https://pred.uni-regensburg.de/id/eprint/49472 |
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