Jensen, Boye L. and Lehle, Ursula and Müller, Markus and Wagner, Charlotte and Kurtz, Armin (1998) Interleukin-1 inhibits renin gene expression in As4.1 cells but not in native juxtaglomerular cells. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 436 (5). pp. 673-678. ISSN 0031-6768, 1432-2013
Full text not available from this repository.Abstract
Cardiovascular effects of inflammatory interleukins (IL) have been suggested to be mediated by the renin-angiotensin system in vivo. To address the direct cellular effect of IL, we examined the influence of IL-1 beta on renin secretion and renin mRNA in cultures of mouse juxtaglomerular granular (JG) cells and in the mouse tumor cell line As4.1, which expresses renin mRNA. Renin mRNA levels and secretion of active renin were not significantly changed by IL-1 beta in native JG cells. Activation of adenylyl cyclase by forskolin increased renin secretion and renin mRNA levels three- and fivefold, respectively. These stimulatory responses to forskolin were not altered by IL-1 beta. In contrast to native JG cells, renin mRNA abundance was markedly suppressed by IL-1 beta in As4.1 cells, whereas secretion of active renin and the stability of renin mRNA were not changed. In As4.1 cells forskolin did not change renin secretion or renin mRNA abundance in the absence or in the presence of IL-1 beta. These findings suggest that IL-1 beta has no direct influence on renin secretion and renin mRNA abundance at the level of native JG cells.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TUMOR-NECROSIS-FACTOR; HUMAN DECIDUAL CELLS; RECOMBINANT INTERLEUKIN-2; ALDOSTERONE SYSTEM; MOLECULAR-BIOLOGY; SECRETION; PRORENIN; MOUSE; INFUSION; RELEASE; kidney; mRNA; secretion |
| Subjects: | 500 Science > 570 Life sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Physiologie > Prof. Dr. Armin Kurtz |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 16 Feb 2023 06:41 |
| Last Modified: | 16 Feb 2023 06:41 |
| URI: | https://pred.uni-regensburg.de/id/eprint/49477 |
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