Gruss, Claus and Behrens, S. and von Kobyletzki, G. and Reuther, T. and Husebo, L. and Altmeyer, P. and Kerscher, M. (1998) Effects of water temperature on photosensitization in bath-PUVA therapy with 8-methoxypsoralen. PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE, 14 (5-6). pp. 145-147. ISSN 0905-4383, 1600-0781
Full text not available from this repository.Abstract
The pharmacokinetic aspects of bath-PUVA are not completely clarified. Therefore, we determined the phototoxic response of human skin following psoralen baths at temperatures ranging from 32 degrees C to 42 degrees C (71.6-107.6 degrees F) and UVA doses ranging from 0.5 to 5.5 J/cm(2). The highest therapeutical photosensitization (i.e., lowest minimal phototoxic dose) was assessed at temperatures of 37 degrees C (98.6 degrees F) and above. Photosensitization was significantly decreased at lower temperatures. These data indicate that a bath temperature of 37 degrees C (98.6 degrees F) should be used to gain optimal therapeutic efficiency in a clinical setting. Furthermore, in order to minimize the risk of adverse phototoxic effects in bath-PUVA, it is important to use a constant temperature during the psoralen bath.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PSORIASIS; DELIVERY; bath-PUVA; 8-methoxypsoralen; water temperature; photosensitization |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Dermatologie und Venerologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 18 Apr 2023 13:54 |
| Last Modified: | 18 Apr 2023 13:54 |
| URI: | https://pred.uni-regensburg.de/id/eprint/49478 |
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