Iro, H. and Voelklein, B. A. and Waldfahrer, F. and Schneider, T. and Riedlinger, R. E. and Zenk, J. (1998) Cytotoxic and anti-proliferative effects of high-energy pulsed ultrasound (HEPUS) on human squamous cell carcinoma cells as compared to connective tissue fibroblasts. EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY, 255 (8). pp. 420-426. ISSN 0937-4477,
Full text not available from this repository.Abstract
The cytotoxic and anti-proliferative effects of high-energy pulsed ultrasound (HEPUS) on human squamous cell carcinoma cells cloned from the hypopharynx (FaDu) and benign connective tissue cells (fibroblasts) were investigated in vitro. Sonication was carried out using an experimental piezoelectric, self-focusing burst-signal transducer. To increase the induction of cavitation, the transducer used was specifically designed to produce multiple oscillations with a high negative pressure amplitude. In both cell lines tested, the application of 100, 800 and 2000 pulses resulted in a high reduction of vital cells. After 2000 pulses, 4.0 +/- 1.1% of the fibroblasts but only 2.0 +/- 0.3% of the FaDu cells survived HEPUS exposure. A postexposure inhibiting effect of HEPUS for 10 days on the proliferation of surviving cells was noted for the FaDu cells exposed to 2000 pulses, but not as much for the fibroblasts. These findings support the hypothesis that human squamous cell carcinoma cells of the hypopharynx might be more sensitive to HEPUS than fibroblasts and that total tumor cell ablation might be possible in vitro given a sufficient number of HEPUS pulses.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SHOCK-WAVES; INVITRO; CAVITATION; hypopharyngeal malignancy; cancer therapy; high-energy pulsed ultrasound; cell destruction; cavitation |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Hals-Nasen-Ohren-Heilkunde |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 25 Apr 2023 13:01 |
| Last Modified: | 25 Apr 2023 13:01 |
| URI: | https://pred.uni-regensburg.de/id/eprint/49543 |
Actions (login required)
 |
View Item |
