Gruss, Claus and Behrens, Stefanie and Reuther, Tilmann and Husebo, Lise and Neumann, Norbert and Altmeyer, Peter and Lehmann, Percy and Kerscher, Martina (1998) Kinetics of photosensitivity in bath-PUVA photochemotherapy. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 39 (3). pp. 443-446. ISSN 0190-9622,
Full text not available from this repository.Abstract
Background: Bath-PUVA is used to treat a variety of dermatoses. However, the kinetics of 8-methoxypsoralen during treatment are not completely clarified. Objective: The purpose of this study was to investigate the intensity of the phototoxic response and the persistence of phototoxicity after bath-PUVA. Methods: Twelve volunteers were exposed to WA doses ranging from 0.5 to 40 J/cm(2) from 10 to 240 minutes after bath-PUVA treatment. The resulting phototoxic response of the skin was determined. Results: Irradiation 10 minutes after the psoralen bath led to the lowest assessed minimal phototoxic dose (MPD) of 1.42 J/cm(2) (mean, SD +/- 0.29). Thereafter, the MPD increased significantly and sharply every hour. At 4 hours after the psoralen bath, UVA doses up to 40 J/cm(2) failed to induce any phototoxic erythema (MPD). Conclusion: For optimal effects, UVA irradiation has to be administered immediately after the psoralen bath; no restrictive behavior is necessary after bath-PUVA treatment.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | 8-METHOXYPSORALEN; THERAPY; PSORIASIS; DELIVERY; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Dermatologie und Venerologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 25 Apr 2023 13:32 |
| Last Modified: | 25 Apr 2023 13:32 |
| URI: | https://pred.uni-regensburg.de/id/eprint/49566 |
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