Mueller, K. and Ziereis, K. and Paper, D. (1998) Ilex aquifolium: Protection against enzymatic and non-enzymatic lipid peroxidation. PLANTA MEDICA, 64 (6). pp. 536-540. ISSN 0032-0943, 1439-0221
Full text not available from this repository. (Request a copy)Abstract
The ethanolic extract of Ilex aquifolium L. (Aquifoliaceae) concentration-dependently inhibited leukotriene B-4 biosynthesis in isolated bovine PMNL with an IC50 value of about 60 mu g/ml, whereas the effect on epidermal 12(S)-HETE biosynthesis was much less pronounced. The extract also inhibited the non-enzymatic, peroxyl radical-stimulated lipid peroxidation in model membranes and was further a scavenger of the iron-dependent generation of hydroxyl radicals from hydrogen peroxide as determined by protection against deoxyribose degradation. While inhibition of leukotriene biosynthesis was not mediated by its known phenolic constituents such as hyperoside, rutoside, and chlorogenic acid, these compounds were responsible for the inhibitory effects of I. aquifolium against nonenzymatic lipid peroxidation and deoxyribose degradation.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ANTIPSORIATIC ANTHRONES; 5-LIPOXYGENASE; ANTIOXIDANT; INHIBITION; FLAVONOIDS; RADICALS; MALONDIALDEHYDE; ADDITIVES; MEMBRANES; DAMAGE; anti-inflammatory activity; Ilex aquifolium L. (holly); Aquifoliaceae; deoxyribose degradation; leukotriene B-4; lipid peroxidation; 5-lipoxygenase |
| Subjects: | 600 Technology > 615 Pharmacy |
| Divisions: | Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry I (Prof. Elz) Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Biology (Prof. Heilmann) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 02 May 2023 12:27 |
| Last Modified: | 02 May 2023 12:27 |
| URI: | https://pred.uni-regensburg.de/id/eprint/49649 |
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