Rath, Heiko C. and Andus, Tilo and Caesar, Inka and Schoelmerich, Juergen (1998) Initial symptoms, extraintestinal manifestations and course of pregnancy in 392 patients with inflammatory bowel disease. MEDIZINISCHE KLINIK, 93 (7). pp. 395-400. ISSN 0723-5003, 1615-6722
Full text not available from this repository. (Request a copy)Abstract
Background: In many cases inflammatory bowel disease is accompanied by extraintestinal manifestations. This results in lowering of live quality. The aim of this study was to gather data retrospectively about initial symptoms, extraintestinal manifestations and course of pregnancy in a large unselected population with inflammatory bowel disease in South Germany. Patients and Methods: Data from 1975 to 1989 (392 patients) were analyzed and partially compared with data from 1992 to 1995 (211 patients). Results: Patients with Crohn's disease in average have been 25 years old at the time point of initial symptoms, whereas the age of ulcerative coli;is patients was 30 years (p < 0.0001). The number of Crohn's disease patients with a long interval between initial symptoms and diagnosis (> 1 year) was significantly decreased in the second population (50% vs 38%; p < 0.05). Dominant initial symptom in Crohn's disease were indisposition, abdominal pain and non-bloody diarrhea in contrast to ulcerative colitis which manifested mostly with bloody diarrhea. Extraintestinal manifestations occurred in 76% of patients with Crohn's disease and 64.6% with ulcerative colitis. Complications during the course of pregnancy have been detected in 40.5% in Crohn's disease and 60% in ulcerative colitis. Conclusion: A better knowledge of initial symptoms and extraintestinal manifestations in inflammatory bowel disease can help to decrease the interval between initial symptoms and the diagnosis. Pregnancy in patients with inflammatory bowel disease needs to be treated with special care.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CROHNS-DISEASE; ULCERATIVE-COLITIS; POPULATION; PREVALENCE; COMPLICATIONS; EPIDEMIOLOGY; PATHOGENESIS; ARTHRITIS; COMMUNITY; HLA-B27; inflammatory bowel disease; extraintestinal manifestations; initial symptoms; pregnancy |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 02 May 2023 13:35 |
| Last Modified: | 02 May 2023 13:35 |
| URI: | https://pred.uni-regensburg.de/id/eprint/49671 |
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