Wirtz, Hans-Christian and Mueller, Wolfram and Noguchi, Tsuyoshi and Scheven, Melanie and Rueschoff, Josef and Hommel, Gerd and Gabbert, Helmut Erich (1998) Prognostic value and clinicopathological profile of microsatellite instability in gastric cancer. CLINICAL CANCER RESEARCH, 4 (7). pp. 1749-1754. ISSN 1078-0432,
Full text not available from this repository.Abstract
In this study, microsatellite instability (MI) was investigated in 126 gastric carcinomas and correlated with clinicopathological features and prognosis; at least 5-10 microsatellite loci were analyzed. MI was identified in 56 (44.5%) of all investigated carcinomas, one locus being affected in 40 (31.7%) carcinomas, two loci being affected in 6 (4.8%) carcinomas, and more than two loci being affected in 10 (8.0%) carcinomas. MI was correlated with neither age and sex of the patients nor with depth of invasion, lymph node metastasis, tumor differentiation, or histological type according to WHO and Lauren classification. The frequency of MI was the same in early gastric carcinomas as it was in advanced gastric carcinomas, suggesting that MI arises early during the tumorigenesis of gastric cancer. No significant differences in survival could be demonstrated between patients with MI-negative and MI-positive gastric carcinomas.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | NONPOLYPOSIS COLORECTAL-CANCER; POLYMERASE CHAIN-REACTION; GENOMIC INSTABILITY; FAMILY HISTORY; COLON-CANCER; MUTATIONS; CARCINOMA; ADENOCARCINOMA; ASSOCIATION; SEQUENCES; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 09 May 2023 06:49 |
| Last Modified: | 09 May 2023 06:49 |
| URI: | https://pred.uni-regensburg.de/id/eprint/49688 |
Actions (login required)
 |
View Item |
