Holmer, S. R. and Hense, Hans-Werner and Danser, A. H. J. and Mayer, B. and Riegger, Guenter A. J. and Schunkert, Heribert (1998) beta Adrenergic blockers lower renin in patients treated with ACE inhibitors and diuretics. HEART, 80 (1). pp. 45-48. ISSN 1355-6037,
Full text not available from this repository.Abstract
Objective-To examine the effect of concomitant intake of beta blockers with angiotensin converting enzyme (ACE) inhibitors, diuretics, or both on plasma renin concentrations in a population based sample (MONICA survey, Augsburg, Germany). Subject and methods-728 individuals were studied, of whom 171 were treated using monotherapy (ACE inhibitor (n = 21), diuretic (n = 10), or beta blocker (n = 72)), or combination treatment (ACE inhibitor + diuretic (n = 32), ACE inhibitor + beta blocker (n = 7),diuretic + beta blocker (n = 22), ACE inhibitor + diuretic + beta blocker (n = 7)). The remaining 557 individuals were untreated. Indications for treatment were hypertension (75%), coronary artery disease with (12%) or without (3%) hypertension, or unknown (10%). Results-Mean (SEM) renin concentrations in individuals treated with an ACE inhibitor (41 (8)mU/1), a diuretic (41 (10) mU/1), or the combination of an ACE inhibitor and a diuretic (54 (10) mU/1) were raised compared with untreated individuals (17 (1) mU/1; p < 0.05 each). Monotherapy with a beta blocker, however, decreased mean renin concentrations (12 (1) mU/1; p < 0.01 upsilon untreated). Renin concentrations in individuals taking a beta blocker with either an ACE inhibitor (21 (8) mU/1), or a diuretic (22 (4) mU/1), or with both an ACE inhibitor and a diuretic (21 (7)mU/L), were significantly lower compared with renin concentrations in groups not receiving beta blocker treatment (p < 0.05 each). Conclusion-These data suggest that the upregulation of renin by treatment with ACE inhibitors, diuretics, or both can be largely prevented by concomitant beta blocker treatment.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ANGIOTENSIN-II; HEART-FAILURE; HYPERTENSION; RELEASE; adrenergic beta receptor blocker; angiotensin converting enzyme inhibitor; renin; hypertension |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 09 May 2023 07:11 |
| Last Modified: | 09 May 2023 07:11 |
| URI: | https://pred.uni-regensburg.de/id/eprint/49696 |
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