Lock, Guntram and Straub, Rainer H. and Zeuner, M. and Antoniou, E. and Holstege, A. and Schoelmerich, Juergen and Lang, B. (1998) Association of autonomic nervous dysfunction and esophageal dysmotility in systemic sclerosis. JOURNAL OF RHEUMATOLOGY, 25 (7). pp. 1330-1335. ISSN 0315-162X,
Full text not available from this repository. (Request a copy)Abstract
Objective. The primary event in the pathogenesis of gastrointestinal involvement in systemic sclerosis (SSc) has been hypothesized to be an early neural lesion. We investigated the association of autonomic nervous dysfunction and esophageal involvement in SSc.; Methods. Thirty-six consecutive patients with SSc were investigated by esophageal manometry and autonomic nervous function tests for cardiovascular and pupillary autonomic dysfunction. Results. In 27 of 36 patients, esophageal manometry showed esophageal dysfunction. Twelve patients had either pupillary (n = 6) or cardiovascular (n = 5) dysfunction or both (n = 1). All patients with autonomic dysfunction had esophageal dysfunction. Patients with autonomic dysfunction had significantly reduced mean distal esophageal contraction amplitudes compared to patients without autonomic nervous dysfunction (p<0.05). The association of autonomic dysfunction and esophageal dysfunction was significant (p = 0.02). Conclusion, Our results support the concept of a role for neurogenic defects in the development of esophageal dysfunction in SSc.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PUPILLARY LIGHT REFLEX; HEART-RATE-VARIABILITY; GASTROESOPHAGEAL REFLUX; DIABETES-MELLITUS; SCLERODERMA; NEUROPATHY; MANIFESTATIONS; MOTILITY; PATHOGENESIS; PARAMETERS; esophageal manometry; scleroderma; autonomic function test; autonomic neuropathy |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 09 May 2023 08:08 |
| Last Modified: | 09 May 2023 08:08 |
| URI: | https://pred.uni-regensburg.de/id/eprint/49704 |
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