Sellmer, Andreas and Terpetschnig, Ewald and Wiegrebe, Wolfgang and Wolfbeis, Otto S. (1998) UV/Vis and fluorescence study on anthralin and its alkylated derivatives. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY, 116 (1). pp. 39-45. ISSN 1010-6030
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Anthralin 1 and some of its C-10 or O-alkylated derivatives were investigated by UV/VIS- and fluorescence spectroscopy in different solvents and buffer systems, respectively. The effects of substituents on the formation of anthralin anion as well as the constitution of the resulting anions confirm that C-H acidity at position 10 is necessary for the formation of a fully aromatic anionic form. It is concluded that the resulting anion la is the pharmacologically active species of the antipsoriatic anthralin. Tautomerism of the neutral molecule is not observable. (C) 1998 Elsevier Science S.A. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ANTIPSORIATIC ANTHRONES; DITHRANOL; ANTHRACENONES; anthralin; UV/Vis spectroscopy; fluorescence spectroscopy; alkylated derivatives |
| Subjects: | 500 Science > 540 Chemistry & allied sciences 600 Technology > 615 Pharmacy |
| Divisions: | Chemistry and Pharmacy > Institute of Pharmacy > Alumni or Retired Professors > Prof. Wiegrebe Chemistry and Pharmacy > Institut für Analytische Chemie, Chemo- und Biosensorik |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 24 Feb 2023 06:16 |
| Last Modified: | 24 Feb 2023 06:16 |
| URI: | https://pred.uni-regensburg.de/id/eprint/49725 |
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