Straub, Rainer H. and Glueck, T. and Zeuner, M. and Schoelmerich, Juergen and Lang, B. (1998) Association of pupillary parasympathetic hyperreflexia and systemic inflammation in patients with systemic lupus erythematosus. BRITISH JOURNAL OF RHEUMATOLOGY, 37 (6). pp. 665-670. ISSN 0263-7103,
Full text not available from this repository. (Request a copy)Abstract
In chronic inflammatory diseases, cytokines stimulate the hypothalamus-pituitary-adrenal axis and the hypothalamus-autonomic nervous system (HANS) axis. The present study was performed to find autonomic nervous function parameters in patients with systemic lupus erythematosus (SLE) which are suitable to demonstrate the activation of the HANS axis during systemic inflammation. Thirty-four patients with SLE (age 35.3 +/- 1.9 yr) were investigated by seven standardized autonomic nervous function tests. The SLEDAI and laboratory parameters of systemic inflammation were assessed by standard techniques. Pupillary latency time hyperreflexia was found in 29.4%, whereas maximal pupillary area was hyperresponsive in only 2.9%. A total of 12% had overall cardiovascular autonomic nervous hyperreflexia. Patients with latency time hyperreflexia had more severe systemic inflammation [erythrocyte sedimentation rate (ESR): P < 0.001; C-reactive protein (CRP): P = 0.0094; fibrinogen: P < 0.001; albumin: P = 0.003; antinuclear antibodies: P = 0.020]. The longitudinal study of 13 patients during 4 yr demonstrated a parallel increase and decrease in latency time percentile and ESR. SLE patients with increased systemic inflammation had an activated HANS axis which can be measured by a parasympathetic pupillary reflex test.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CARDIOVASCULAR AUTONOMIC FUNCTION; NOREPINEPHRINE TURNOVER; IMMUNE; NEUROPATHY; INTERLEUKIN-1; SPLEEN; REFLEX; TESTS; RATS; autonomic nervous function; systemic lupus erythematosus; parasympathetic pupillary hyperreflexia; systemic inflammation; hypothalamus |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 09 May 2023 09:01 |
| Last Modified: | 09 May 2023 09:01 |
| URI: | https://pred.uni-regensburg.de/id/eprint/49748 |
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