Fingerle-Rowson, G. and Angstwurm, M. and Andreesen, Reinhard and Ziegler-Heitbrock, H. W. L. (1998) Selective depletion of CD14(+)CD16(+) monocytes by glucocorticoid therapy. CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 112 (3). pp. 501-506. ISSN 0009-9104, 1365-2249
Full text not available from this repository.Abstract
Glucocorticoids (GC) are potent anti-inflammatory and immunosuppressive agents that act on many cells of the body, including monocytes. Here we show that a 5-day course of high dose GC therapy differentially affected the CD14(++) and the CD14(+)CD16(+) monocyte subpopulations in 10 patients treated for multiple sclerosis. While the classical (CD14(++)) monocytes exhibited a substantial increase from 495 +/- 132 to 755 +/- 337 cells/mu l, the CD14(+) CD16(+) monocytes responded with a pronounced decrease from 36 +/- 15 to 2 +/- 3 cells/mu l (P<0.001). In 4/10 patients the CD14(+) CD16(+) monocytes fell below detection limits (<0.2 cells/mu l). This observation was confirmed when the CD14(+)CD16(+) monocytes were identified by virtue of their low CD33 expression as these cells decreased as well. After discontinuation of GC therapy the CD14(+) CD16(+) monocytes reappeared and reached normal levels after 1 week. The profound depletion of CD14(+) CD16(+) monocytes by GC as described here is a novel effect of GC action in vivo and may contribute to GC-mediated immunosuppression. Determination of the number of this monocyte subset may also serve to monitor the effectiveness of GC therapy in patients requiring immunosuppressive treatment.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | COLONY-STIMULATING FACTOR; INTERCELLULAR-ADHESION MOLECULE-1; NECROSIS-FACTOR SYNTHESIS; HUMAN PERIPHERAL-BLOOD; KAPPA-B ACTIVITY; ENDOTHELIAL-CELLS; POLYMORPHONUCLEAR LEUKOCYTES; MEDIATED REPRESSION; NONHUMAN-PRIMATES; EXPRESSION; glucocorticoids; CD14(+)CD16(+) monocyte; immunosuppression; multiple sclerosis |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 09 May 2023 09:06 |
| Last Modified: | 09 May 2023 09:06 |
| URI: | https://pred.uni-regensburg.de/id/eprint/49749 |
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