Szalay, Katalin S. and Orso, E. and Juranyi, Z. and Vinson, G. P. and Vizi, E. S. (1998) Local non-synaptic modulation of aldosterone production by catecholamines and ATP in rat: Implications for a direct neuronal fine tuning. HORMONE AND METABOLIC RESEARCH, 30 (6-7). pp. 323-328. ISSN 0018-5043, 1439-4286
Full text not available from this repository.Abstract
In addition to hypophyseal control, steroid synthesis and secretion in the adrenal cortex is also under direct local neural modulation. We obtained morphological and neurochemical evidence that a substantial proportion of the noradrenergic nerve endings lie in close proximity to zona glomerulosa cells without making synaptic contact, thus providing evidence for a direct local modulatory role of catecholamines in steroid secretion. These noradrenergic neurones, like other noradrenergic neurones in the central nervous system, are able to take up dopamine (DA), convert it partly into noradrenaline (NA) and to release both NA and DA together with the co-transmitter ATP when neuronal activity drives them to do so. These catecholamines and ATP may reach zona glomerulosa cells via diffusion in a paracrine way and modulate the synthesis of aldosterone. The presence of ecto-Ca-ATPases, enzymes that may terminate the effect of ATP, was demonstrated around the nerve profiles indicating that not only ATP but its metabolites (ADP, AMP, adenosine) can also influence the production of aldosterone. These data strongly support the possibility of a paracrine, non-synaptic modulatory role of catecholamines and ATP in the regulation of adrenocortical steroid secretion.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ADRENOCORTICAL-FASCICULATA CELLS; ADRENAL GLOMERULOSA CELLS; BETA-ADRENERGIC STIMULATION; DOPAMINE-RECEPTORS; GLUCOCORTICOID SECRETION; MORPHOLOGICAL EVIDENCE; SIGNAL-TRANSDUCTION; STEROID-SECRETION; EXTRACELLULAR ATP; ADENYLATE-CYCLASE; adrenal cortex; zona glomerulosa; noradrenaline; dopamine; neural regulation |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 09 May 2023 09:28 |
| Last Modified: | 09 May 2023 09:28 |
| URI: | https://pred.uni-regensburg.de/id/eprint/49760 |
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