Eichhammer, Peter and Walz, A. and Mengling, T. and Schoeler, A. and Putzhammer, A. and Rohrmeier, T. and Aigner, J. M. and Klein, H. E. and Schlegel, J. (1998) Detection of polymorphic triplet repeats in the genomes of patients suffering from bipolar affective disorder. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 1 (6). pp. 989-993. ISSN 1107-3756,
Full text not available from this repository.Abstract
Evidence for the operation of expanded trinucleotide repeats in the pathogenesis of bipolar affected disorder has recently been found at the molecular genetic level. For the screening of these repeat motifs in genomes of patients with bipolar affective disorder, we established a modified PCR-based fingerprinting technique, called triplet repeat enhanced arbitrarily primed PCR (TREAP-PCR). Using this approach, 40 patients suffering from bipolar affective disorder (ICD10: F31) and 15 healthy controls were investigated. Interindividual polymorphisms generated by TREAP-PCR seemed to depend on the type of triplet. Using CCG triplet primers, polymorphisms could be observed more often in the genomes of patients compared with controls, whereas no significant differences could be found using primers of the CAG or AAT type. These data might indicate the existence of subgroups of manic-depressive patients based on molecular genetic differences.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | EXPANDED CAG/CTG REPEATS; CAG REPEAT; SCHIZOPHRENIA; ANTICIPATION; EXPANSION; ASSOCIATION; DISEASE; ATAXIA; ONSET; GENES; polymorphic triplet repeats; bipolar affective disorder |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 09 May 2023 09:44 |
| Last Modified: | 09 May 2023 09:44 |
| URI: | https://pred.uni-regensburg.de/id/eprint/49762 |
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