Danser, A. H. Jan and Derkx, Frans H. M. and Schalekamp, Maarten A. D. H. and Hense, Hans-Werner and Riegger, Guenter A. J. and Schunkert, Heribert (1998) Determinants of interindividual variation of renin and prorenin concentrations: evidence for a sexual dimorphism of (pro)renin levels in humans. JOURNAL OF HYPERTENSION, 16 (6). pp. 853-862. ISSN 0263-6352, 1473-5598
Full text not available from this repository. (Request a copy)Abstract
Background Plasma renin concentrations are an important factor in cardiovascular risk profiling, Objective To investigate the effects of sex, medication, and anthropometric factors that may contribute to the interindividual variation in the plasma concentrations of renin and its precursor prorenin, Design and methods Prorenin and renin levels in 327 men and 383 women, aged 52-69 years, who participated in a 1994 reexamination of a previous population survey in Bavaria, were measured by immunoradiometric assay. Results Prorenin and renin levels in men were significantly higher than those in women, those in women without estrogen replacement therapy were significantly higher than those in women with estrogen replacement therapy, and those in diabetics were significantly higher than those in nondiabetics. Prorenin level was correlated negatively to blood pressure and positively to age and the use of diuretics; it was normal in subjects using angiotensin converting enzyme inhibitors and beta-adrenergic antagonists (beta-blockers), Renin level was correlated negatively to atrial natriuretic peptide level and the use of beta-blockers, and it was elevated above normal revels in subjects using angiotensin converting enzyme inhibitors and diuretics as well as in subjects who had previously suffered myocardial infarction, After exclusion of data for women being administered estrogen replacement therapy, multivariate analysis revealed that sex (P< 0.001), age (P< 0.02), blood pressure (P< 0.002), diabetes (P < 0.05), and the use of angiotensin converting enzyme inhibitors (P < 0.002), beta-blockers (P < 0.001), and diuretics (P < 0.05) were independent determinants of plasma prorenin, Plasma renin was independently related to atrial natriuretic peptide level (P< 0.01) and the use of angiotensin converting enzyme inhibitors (P < 0.001), beta-blockers (P < 0.001), and diuretics (P < 0.05), Conclusions These data demonstrate that there is a sexual dimorphism of prorenin levels in humans, suggesting that sex hormones affect the regulation of the renin gene, Data confirm previous reports of elevated prorenin levels in diabetics and older subjects, as well as of lower than normal prorenin levels in subjects with hypertension in smaller populations, Our findings may help to clarify the potential (patho)physiologic functions of prorenin and to identify the factors that influence the constitutive secretion and intracellular processing of this prohormone, (C) 1998 Lippincott-Raven Publishers.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MESSENGER-RNA EXPRESSION; PLASMA PRORENIN; INACTIVE RENIN; DIABETES-MELLITUS; MICE; SECRETION; TISSUE; ANGIOTENSINOGEN; COMPLICATIONS; INHIBITION; renin; prorenin; angiotensin converting enzyme inhibitor; beta-adrenergic antagonist; diuretic; diabetes; sexual dimorphism |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 09 May 2023 14:02 |
| Last Modified: | 09 May 2023 14:02 |
| URI: | https://pred.uni-regensburg.de/id/eprint/49772 |
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